Fig. 1 · Structure
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Cas9-IN-2
Cas9 Inhibitor
Cas9-IN-2 is a potent inhibitor of Cas9, with an IC50 of 246 μM. It functions by binding to apo-Cas9, thereby preventing the formation of the Cas9:gRNA complex. This mechanism allows for the modulation and control of Cas9 activity, making Cas9-IN-2 a valuable tool for researchers studying gene editing and its regulatory mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1030133-34-6 |
| Applications | Cas9 Inhibitor |
| Formula | C21H27N5O4S2 |
| Molecular Weight | 477.60 |
| SMILES | O=S(NC1=NOC(C)=C1)(C2=C(C)N(C(C3=NC(C)=C(C(N4CCC(CC4)C)=O)S3)=C2)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.