Fig. 1 · Structure
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CB3731
N-10-(fluoroethyl)quinazolinylfolate Analogue
CB3731 is an analogue of N-10-(fluoroethyl)quinazolinylfolate, targeting thymidylate synthase. This compound is particularly useful for fluorine-19 nuclear magnetic resonance studies, facilitating the investigation of binary and ternary complexes involving the enzyme. Its applications lie in the understanding of enzyme mechanisms and the design of potential therapeutic agents targeting DNA synthesis pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 80015-07-2 |
| Applications | N-10-(fluoroethyl)quinazolinylfolate Analogue |
| Formula | C23H24FN5O6 |
| Molecular Weight | 485.46 |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=CC=C3NC(N)=NC(C3=C2)=O)CCF)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.