Fig. 1 · Structure
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CBP-1018
PDC
CBP-1018 is a peptide-drug conjugate (PDC) designed to target FLOR1 and prostate-specific membrane antigen (PSMA) for enhanced tumor specificity. By conjugating Monomethyl auristatin E to a dual-targeting ligand through a specialized linker, CBP-1018 exhibits potent cytotoxicity against target cells. This compound is valuable for research applications focused on solid tumors and metastatic castration-resistant prostate cancer, facilitating studies aimed at developing targeted chemotherapy strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2923068-30-6 |
| Applications | PDC |
| Formula | C132H192N30O38S |
| Molecular Weight | 2839.18 |
| SMILES | [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN4C(=O)C(SC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CC5=CC=C(CNC(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C=C5)=O)CC(O)=O)=O)CC(O)=O)=O)CCCCN)=O)C(N[C@@H](CCCCNC(CC[C@H](NC(=O)C6=CC=C(NCC=7N=C8C(NC7)=NC(N)=NC8=O)C=C6)C(O)=O)=O)C(N)=O)=O)CC4=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)[C@H](C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.