Fig. 1 · Structure
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CBP/p300-IN-2
Epigenetic Reader Domain Inhibitor
CBP/p300-IN-2 is a potent inhibitor targeting the CBP/EP300 proteins, exhibiting IC50 values of 1.07 nM against CBP/HTRF and 5.96 nM against the Myc oncogene. This compound is essential for studies investigating the role of epigenetic modulation in gene regulation and the potential therapeutic applications in cancer and other diseases linked to dysregulated CBP/EP300 activity. Its selective inhibition provides a valuable tool for elucidating the functions of these critical epigenetic reader domains in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2158265-96-2 |
| Applications | Epigenetic Reader Domain Inhibitor |
| Formula | C27H29F2N7O2 |
| Molecular Weight | 521.56 |
| SMILES | O=C(N1CCC(N(C2CCOCC2)N=C3C4=CN=CC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.