Fig. 1 · Structure
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CBR-3465
Type II NADH Dehydrogenase Inhibitor
CBR-3465 is an inhibitor of Type II NADH dehydrogenase, specifically targeting the enzyme in Mycobacterium tuberculosis (Mtb). This compound exhibits significant antimicrobial activity, demonstrated by a minimum inhibitory concentration (MIC) of 0.16 μM against Mtb, making it a valuable tool for research into tuberculosis treatment and drug development. Its precise mechanism and potency provide a basis for studying the role of NADH dehydrogenase in mycobacterial metabolism and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2225883-59-8 |
| Applications | Type II NADH Dehydrogenase Inhibitor |
| Formula | C16H18FN3O2S |
| Molecular Weight | 335.40 |
| SMILES | O=C1N=C(NC2=C1C(F)=CC=C2)SCC(NC3CCCCC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.