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cBu-Cit-GAL-02-221

PROTAC-Linker Conjugate

cBu-Cit-GAL-02-221 is a PROTAC-linker conjugate designed to facilitate the degradation of BRD4 through its association with cBu-Cit. This compound effectively inhibits BRD4 activity in both HER2-positive and HER2-negative breast cancer cell lines, making it a valuable tool for cancer research. Additionally, cBu-Cit-GAL-02-221 features a single bond, allowing for conjugation with antibody-drug conjugates (ADCs) to create a potent pharmacological agent.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2417369-73-2
Applications	PROTAC-Linker Conjugate
Formula	C₇₉H₉₉ClN₁₆O₁₆S₂
Molecular Weight	1628.31
Synonyms	cBu-Cit-PROTAC BRD4 Degrader-5
SMILES	CC1=C(C)SC(N2C3=NN=C2C)=C1C(C4=CC=C(C=C4)Cl)=N[C@H]3CC(NCCOCCOCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(NCC(C=C6)=CC=C6C7=C(C)N=CS7)=O)OCNC(OCC8=CC=C(NC([C@@H](NC(C9(C(NCCCCCN%10C(C=CC%10=O)=O)=O)CCC9)=O)CCCNC(N)=O)=O)C=C8)=O)=O)C(C)(C)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.