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Cbz-QFR-kbt

TMPRSS2 Inhibitor

Cbz-QFR-kbt is a potent TMPRSS2 inhibitor classified as a ketone-based benzothiazole. It exhibits a remarkable IC50 value of 0.42 nM against TMPRSS2 and also demonstrates inhibitory activity towards Matriptase, Hepsin, HGFA, and Factor Xa, with respective IC50 values of 1, 1.3, 85, and 85 nM. Additionally, Cbz-QFR-kbt effectively inhibits SARS-CoV-2 and H1N1 viral strains with an IC50 of 60 nM. This compound serves as a valuable tool for antiviral research and the study of protease-mediated processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3086979-57-6
Applications	TMPRSS2 Inhibitor
Formula	C₃₅H₄₀N₈O₆S
Molecular Weight	700.81
SMILES	NC(NCCC[C@@H](C(C1=NC(C=CC=C2)=C2S1)=O)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(N)=O)NC(OCC4=CC=CC=C4)=O)=O)=O)=N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.