CbzNH-PEG4-CH2COOH is a PEG-based linker featuring a carboxylic acid group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer enhances the solubility of compounds in aqueous environments. The terminal carboxylic acid readily reacts with primary amines, particularly in the presence of activators like HATU, facilitating the formation of stable amide bonds. Furthermore, the benzyl protecting group can be effectively removed through hydrogenolysis, yielding a free amine for subsequent reactions. This reagent is valuable for a variety of biochemical assays and compound modification applications.
CbzNH-PEG4-CH2COOH is a PEG-based linker featuring a carboxylic acid group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer enhances the solubility of compounds in aqueous environments. The terminal carboxylic acid readily reacts with primary amines, particularly in the presence of activators like HATU, facilitating the formation of stable amide bonds. Furthermore, the benzyl protecting group can be effectively removed through hydrogenolysis, yielding a free amine for subsequent reactions. This reagent is valuable for a variety of biochemical assays and compound modification applications.
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