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CC-11

Small Molecule Drug Conjugate

CC-11 is a small molecule drug conjugate (SMDC) designed to target extracellular heat shock protein 90 (HSP90) while inhibiting PI3Kα kinase activity. With a strong binding affinity for HSP90 (IC50 = 15 nM) and potent inhibition of PI3Kα (IC50 = 0.54 nM), CC-11 demonstrates notable anti-proliferative effects against colon cancer cells. It has also shown significant efficacy in HCT-116 xenograft tumor models, making it a valuable tool for research in colon cancer therapeutics.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3079942-94-9
Applications	Small Molecule Drug Conjugate
Formula	C₅₂H₅₄F₂N₁₂O₁₀S
Molecular Weight	1077.12
SMILES	CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.