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CCT070535

TCF Inhibitor

CCT070535 is a TCF inhibitor that disrupts TCF-dependent transcriptional activity. It demonstrates significant inhibition with GI50 values of 17.6 μM in HT29 (APC mutant), 11.1 μM in HCT116 (oncogenic β-catenin), 11.8 μM in SW480 (APC mutant), and 13.4 μM in SNU475 (Axin mutant) cells. This compound is valuable for research applications targeting Wnt signaling pathways and investigating the role of TCF in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	485319-41-3
Applications	TCF Inhibitor
Formula	C₂₀H₁₃Cl₂N₃O₂
Molecular Weight	398.24
SMILES	O=C1C(CC2=CC=CC=C2)=C([O-])[N+]3=NC(Cl)=CC=C3N1C4=CC=C(Cl)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.