Fig. 1 · Structure
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CCT077791
p300 Histone Acetyltransferase Inhibitor
CCT077791 is a selective inhibitor of the p300 histone acetyltransferase, exhibiting an IC50 of 7.3 μM in FlashPlate assays and 2.2 μM in filter assays. This compound effectively reduces the overall acetylation of histones H3 and H4, as well as specific acetylated lysine residues and α-tubulin acetylation. CCT077791 is utilized in the study of colorectal cancer, providing insights into the modulation of epigenetic regulation and its implications in tumor biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 748777-47-1 |
| Applications | p300 Histone Acetyltransferase Inhibitor |
| Formula | C9H5ClN2O3S |
| Molecular Weight | 256.67 |
| SMILES | O=C1C=C(SN1C2=CC=C([N+]([O-])=O)C=C2)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.