CCT367766 formic

CCT367766 formic is a third-generation, cereblon-based heterobifunctional PROTAC and pirin-targeting protein degradation probe (PDP). It effectively depletes pirin protein expression at low concentrations. CCT367766 formic demonstrates moderate affinity for the CRBN–DDB1 complex (IC₅₀ = 490 nM) and strong binding affinity for recombinant pirin and CRBN, with K_d values of 55 nM and 120 nM, respectively. This compound serves as a valuable chemical tool for exploring the biological roles of the largely understudied protein pirin.