Fig. 1 · Structure
Documents & Downloads
CD00509
Tdp1 Inhibitor
CD00509 is a potent inhibitor of the tyrosyl-DNA phosphodiesterase Tdp1, exhibiting an IC50 value of 0.71 μM. By increasing DNA damage, CD00509 promotes apoptosis in MCF-7 breast cancer cells and sensitizes both breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT). This compound serves as a valuable tool for investigating therapeutic strategies in breast cancer research and understanding the role of Tdp1 in cellular response to DNA damage.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 27430-18-8 |
| Applications | Tdp1 Inhibitor |
| Formula | C9H6N2O3S |
| Molecular Weight | 222.22 |
| SMILES | S=C1NC(=O)C(C(N1)=O)=CC2=CC=CO2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.