Fig. 1 · Structure
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CD80-IN-3
CD80 Ihbibitor
CD80-IN-3 is a selective inhibitor of the CD80/CD28 interaction, exhibiting a half-maximal effective concentration (EC50) of 630 nM and a dissociation constant (Kd) of 125 nM. This compound effectively modulates immune responses and is instrumental in research applications focusing on autoimmune diseases, cancer immunotherapy, and T cell regulation. Its ability to disrupt CD80 activity makes it a valuable tool for exploring immune checkpoint pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 486449-65-4 |
| Applications | CD80 Ihbibitor |
| Formula | C17H10FN3O3 |
| Molecular Weight | 323.28 |
| SMILES | FC1=C(NC=C2C3=NN(C4=CC=C(C(O)=O)C=C4)C2=O)C3=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.