Fig. 1 · Structure
Documents & Downloads
Cdc7-IN-18
CDC7 Inhibitor
Cdc7-IN-18 is a selective inhibitor of the CDC7 kinase, demonstrating an IC50 of 1.29 nM against the Cdc7/DBF4 enzyme. This compound exhibits significant antiproliferative effects, with an IC50 value of 53.62 nM in COLO205 colorectal cancer cells. Its efficacy makes Cdc7-IN-18 a valuable tool for research in cell cycle regulation and cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2562329-14-8 |
| Applications | CDC7 Inhibitor |
| Formula | C19H21N5OS |
| Molecular Weight | 367.47 |
| SMILES | O=C1C2=C(NC([C@]3([H])N4CCC(CC4)C3)=N1)C5=C(C6=CNN=C6CCC5)S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.