Fig. 1 · Structure
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Cdk1/2 Inhibitor III
Cdk1/2 Inhibitor
Cdk1/2 Inhibitor III is a potent and selective inhibitor targeting cyclin-dependent kinases 1 and 2, with IC50 values of 0.6 nM and 0.5 nM, respectively. This compound demonstrates a high degree of selectivity, with IC50 values of 32 nM against VEGF-R2 and 140 nM against GSK-3β. In cellular assays, Cdk1/2 Inhibitor III effectively reduces proliferation, exhibiting IC50 values of 20 nM, 35 nM, and 92 nM in HCT-116, HeLa, and A375 cell lines, respectively. Its application is relevant for studies in cancer biology and cell cycle regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 443798-55-8 |
| Applications | Cdk1/2 Inhibitor |
| Formula | C15H13F2N7O2S2 |
| Molecular Weight | 425.44 |
| SMILES | S=C(N1N=C(N)N=C1NC2=CC=C(S(=O)(N)=O)C=C2)NC3=C(F)C=CC=C3F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.