CDK1-IN-1 is a potent inhibitor of cyclin-dependent kinase 1 (CDK1), exhibiting an IC50 value of 161.2 nM in complex with cyclin B. This compound demonstrates significant antiproliferative activity, selectively targeting cancer cells and inducing apoptosis through a p53-dependent mechanism via the intrinsic apoptotic pathway. CDK1-IN-1 is a promising candidate for targeted antitumor therapies in oncology research.
CDK1-IN-1 is a potent inhibitor of cyclin-dependent kinase 1 (CDK1), exhibiting an IC50 value of 161.2 nM in complex with cyclin B. This compound demonstrates significant antiproliferative activity, selectively targeting cancer cells and inducing apoptosis through a p53-dependent mechanism via the intrinsic apoptotic pathway. CDK1-IN-1 is a promising candidate for targeted antitumor therapies in oncology research.
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