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CDK12/13-IN-2

CDK12/13 Inhibitor

CDK12/13-IN-2 is a covalent inhibitor targeting cyclin-dependent kinases 12 and 13, with IC50 values of 15.5 nM and 12.2 nM for CDK12 and CDK13, respectively. This compound effectively inhibits the proliferation of breast cancer cells and is particularly relevant for research into triple-negative breast cancer. Its selective action provides a valuable tool for studying the effects of CDK12/13 inhibition in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3076450-41-1
Applications	CDK12/13 Inhibitor
Formula	C₂₄H₂₂FN₇O₂
Molecular Weight	459.48
SMILES	C=CC(NC1=CC=C(C2=NN3C(C=C2)=NC(CC(NC4=NNC(C5CCC5)=C4)=O)=C3)C=C1F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.