Fig. 1 · Structure
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CDK12/13 ligand 1
ALK Inhibitor
CDK12/13 ligand 1 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with demonstrated inhibition of tyrosine protein kinases including CDK2/CyclinE1 and focal adhesion kinase (FAK). At a concentration of 10 μM, it exhibits a maximum inhibition of 40.63% on ALK kinase activity. This compound is relevant for anti-cancer research, particularly in studies focusing on targeting ALK-dependent signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2244986-40-9 |
| Applications | ALK Inhibitor |
| Formula | C26H26BrN5O |
| Molecular Weight | 504.42 |
| SMILES | O=C(N([C@@H]1CC[C@H](CC1)NC2=CC=C(C=N2)C#N)C3=CC=C(Br)C=C3)NCC4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.