Fig. 1 · Structure
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CDK12-IN-5
CDK12 Inhibitor
CDK12-IN-5 is a selective inhibitor of cyclin-dependent kinase 12 (CDK12), exhibiting a potent inhibitory activity with an IC50 of 23.9 nM in the presence of high ATP (2 mM). This compound shows no significant inhibition against CDK2/Cyclin E or CDK9/Cyclin T1, with IC50 values of 173 μM and 127 μM, respectively, under the same conditions. CDK12-IN-5 is valuable for studies investigating the role of CDK12 in transcriptional regulation and its implications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2651200-35-8 |
| Applications | CDK12 Inhibitor |
| Formula | C18H15F5N8O |
| Molecular Weight | 454.36 |
| SMILES | FC(C1=C2N(N=C1)C(NCC3=NC4=CC=C(F)C(F)=C4N3)=NC(N5CCOCC5)=N2)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.