CDK12-IN-5 is a selective inhibitor of cyclin-dependent kinase 12 (CDK12), exhibiting a potent inhibitory activity with an IC50 of 23.9 nM in the presence of high ATP (2 mM). This compound shows no significant inhibition against CDK2/Cyclin E or CDK9/Cyclin T1, with IC50 values of 173 μM and 127 μM, respectively, under the same conditions. CDK12-IN-5 is valuable for studies investigating the role of CDK12 in transcriptional regulation and its implications in cancer research.
CDK12-IN-5 is a selective inhibitor of cyclin-dependent kinase 12 (CDK12), exhibiting a potent inhibitory activity with an IC50 of 23.9 nM in the presence of high ATP (2 mM). This compound shows no significant inhibition against CDK2/Cyclin E or CDK9/Cyclin T1, with IC50 values of 173 μM and 127 μM, respectively, under the same conditions. CDK12-IN-5 is valuable for studies investigating the role of CDK12 in transcriptional regulation and its implications in cancer research.
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