CDK12-IN-6 is a selective inhibitor of cyclin-dependent kinase 12 (CDK12), demonstrating an IC50 of 1.19 μM at elevated ATP concentrations (2 mM). It exhibits strong specificity, showing no significant inhibition of CDK2/Cyclin E or CDK9/Cyclin T1 at concentrations exceeding 20 μM. This compound is valuable for research into transcription regulation and therapeutic strategies targeting CDK12-related pathways in cancer.
CDK12-IN-6 is a selective inhibitor of cyclin-dependent kinase 12 (CDK12), demonstrating an IC50 of 1.19 μM at elevated ATP concentrations (2 mM). It exhibits strong specificity, showing no significant inhibition of CDK2/Cyclin E or CDK9/Cyclin T1 at concentrations exceeding 20 μM. This compound is valuable for research into transcription regulation and therapeutic strategies targeting CDK12-related pathways in cancer.
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