CDK12-IN-E9 is a potent and selective covalent inhibitor of cyclin-dependent kinase 12 (CDK12), with additional non-covalent inhibitory activity towards CDK9. This compound effectively engages its target while minimizing interaction with ABC transporter-mediated efflux mechanisms. Furthermore, CDK12-IN-E9 demonstrates a weak binding affinity to the CDK7/CyclinH complex, exhibiting an IC50 greater than 1 μM. It holds significant potential for research applications in studying transcriptional regulation and cancer biology.
CDK12-IN-E9 is a potent and selective covalent inhibitor of cyclin-dependent kinase 12 (CDK12), with additional non-covalent inhibitory activity towards CDK9. This compound effectively engages its target while minimizing interaction with ABC transporter-mediated efflux mechanisms. Furthermore, CDK12-IN-E9 demonstrates a weak binding affinity to the CDK7/CyclinH complex, exhibiting an IC50 greater than 1 μM. It holds significant potential for research applications in studying transcriptional regulation and cancer biology.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
