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CDK2/4/6-IN-1

CDK2/4/6 Inhibitor

CDK2/4/6-IN-1 is a potent inhibitor of cyclin-dependent kinases 2, 4, and 6, with IC50 values of 2.5 nM, 23.7 nM, and 44.3 nM, respectively. This compound is valuable for cancer research, allowing for the study of cell cycle regulation and tumor progression. Additionally, CDK2/4/6-IN-1 features an alkyne group enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating bioconjugation and labeling applications in chemical biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2803837-13-8
Applications	CDK2/4/6 Inhibitor
Formula	C₂₂H₂₂N₄O₄S
Molecular Weight	438.50
SMILES	O=S(C1=CC=C(NC2=NC=C3C(N([C@@H]4CCC[C@]4(O)C)C(C(C#C)=C3)=O)=N2)C=C1)(C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.