Fig. 1 · Structure
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CDK2 degrader 2
PROTAC/CDK2 Degrader
CDK2 Degrader 2 is a potent PROTAC targeting cyclin-dependent kinase 2 (CDK2), facilitating its degradation in MKN1 cells with a DC50 value of less than 100 nM. This compound employs a novel design, integrating a ligand for the target protein along with a linker and a ligand for the E3 ligase cereblon (CRBN). CDK2 Degrader 2 is valuable for research applications focused on the regulation of cell cycle progression and the exploration of targeted protein degradation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3030271-16-7 |
| Applications | PROTAC/CDK2 Degrader |
| Formula | C46H57ClN10O6S |
| Molecular Weight | 913.53 |
| SMILES | O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.