Fig. 1 · Structure
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CDK2 degrader 5
CDK2 Degrader
CDK2 Degrader 5 is a targeted degrader for cyclin-dependent kinase 2 (CDK2), achieving a maximum degradation (Dmax) of over 50% and up to 80% in the HiBiT Assay. This compound is integral for probing CDK2's role in cell cycle regulation and cancer biology, making it a valuable tool for researchers investigating therapeutic strategies in oncology. Its selective degradation mechanism allows for a deeper understanding of CDK2 functions in various cellular contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2923574-11-0 |
| Applications | CDK2 Degrader |
| Formula | C29H27N3O5 |
| Molecular Weight | 497.54 |
| SMILES | O=C(NCC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)OCC4=CC=CC(C5=CC=CC=C5)=C4C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.