Fig. 1 · Structure
Documents & Downloads
CDK2 degrader 7
CDK2 Degrader
CDK2 Degrader 7 is an orally active compound that targets cyclin-dependent kinase 2 (CDK2) for selective degradation. It exhibits effective biological activity with DC50 values of 13 nM in MKN1 cells and 17 nM in TOV21G cells, leading to G1 phase arrest in MKN1 cells. Additionally, CDK2 Degrader 7 demonstrates efficacy in achieving tumor stasis in xenograft models of HCC1569 with CCNE1 amplification. This reagent is valuable for investigating the therapeutic potential in CCNE1-amplified cancers.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3030279-55-8 |
| Applications | CDK2 Degrader |
| Formula | C39H46F6N8O5S |
| Molecular Weight | 852.89 |
| SMILES | O=S(C1=CC=C(NC2=NC=C(C(F)(F)F)C(N3C[C@@](C)(O)CCC3)=N2)C(F)=C1)(N[C@H]4[C@@H](F)CN(CC5CCN(C6=CC=C(C(CC7)C(NC7=O)=O)C=C6F)CC5)CC4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.