Fig. 1 · Structure
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CDK2 degrader 8
CDK2 Degrader
CDK2 Degrader 8 is a novel chemical probe designed to target and degrade cyclin-dependent kinase 2 (CDK2). By specifically modulating CDK2 levels, it demonstrates significant anti-tumor activity, making it a valuable tool for investigating solid tumors such as breast cancer and ovarian serous cystadenocarcinoma, as well as liquid tumors like diffuse large B-cell lymphoma and acute myelogenous leukemia. CDK2 Degrader 8 facilitates research into the pathological roles of CDK2 dysregulation in cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3099145-52-2 |
| Applications | CDK2 Degrader |
| Formula | C25H19ClF3N5O5 |
| Molecular Weight | 561.90 |
| SMILES | FC(F)(OC1=CC=C(C2=NN=C(O2)NC3(CC3)C4=CC(Cl)=C5CN(C(C5=C4)=O)C6CCC(NC6=O)=O)C=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.