CDK4/6-IN-12

Catalog No.: A54225
CDK4/6 Inhibitor
CDK4/6-IN-12 is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It demonstrates significant enzymatic inhibitory activity, with IC50 values of 592.3 nM for CDK4 and 3090 nM for CDK6. This compound is valuable for cancer research, particularly in studies exploring cell cycle regulation and therapeutic strategies targeting CDK4/6 in tumor cells.
Grouped product items
Size Price Stock Qty
5mg
$225.00
In stock
10mg
$370.00
In stock
25mg
$740.00
In stock
50mg
$1,155.00
In stock
100mg
$1,800.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCDK4/6-IN-12 is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It demonstrates significant enzymatic inhibitory activity, with IC50 values of 592.3 nM for CDK4 and 3090 nM for CDK6. This compound is valuable for cancer research, particularly in studies exploring cell cycle regulation and therapeutic strategies targeting CDK4/6 in tumor cells.
Product Information
Catalog NumA54225
FormulaC12H10N6
Molecular Weight238.25
CAS Number2445205-24-1
SMILESCC1=CN2C3=NC(N)=NC=C3C(C)=C(C2=N1)C#N
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