Fig. 1 · Structure
Documents & Downloads
CDK4/6-IN-15
CDK4/6 Inhibitor
CDK4/6-IN-15 is a selective inhibitor targeting cyclin-dependent kinases 4 and 6 (CDK4/6). This compound effectively suppresses the proliferation of cancer cells by inducing a G1 phase cell cycle arrest and inhibiting the phosphorylation of retinoblastoma protein (Rb) at serine 780. CDK4/6-IN-15 is valuable in research focused on cancer biology and therapeutic interventions that modulate cell cycle dynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2078047-99-9 |
| Applications | CDK4/6 Inhibitor |
| Formula | C21H27FN8S |
| Molecular Weight | 442.56 |
| SMILES | CNC1=NC(C)=C(C2=NC(NC3=NC=C(N4CCC(N(C)C)CC4)C=C3)=NC=C2F)S1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.