Fig. 1 · Structure
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CDK4/6-IN-20
CDK4/CDK6 Inhibitor
CDK4/6-IN-20 is a potent inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/CDK6), demonstrating IC50 values of 1.9 nM and 14.2 nM, respectively. This compound effectively inhibits cell proliferation, making it a valuable tool for cancer research applications. Its selective inhibition of CDK4/6 contributes to understanding cell cycle regulation and potential therapeutic interventions in malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3033950-84-1 |
| Applications | CDK4/CDK6 Inhibitor |
| Formula | C23H24FN5O2 |
| Molecular Weight | 421.47 |
| SMILES | O[C@@H]1COCC[C@H]1NC2=NC=C(C#N)C(C3=CC(C4(CCCC4)C(C)=N5)=C5C(F)=C3)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.