Fig. 1 · Structure
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CDK4/6-IN-3
CDK4/CDK6 Inhibitor
CDK4/6-IN-3 is a potent inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), demonstrating Ki values of less than 0.3 nM and 2.2 nM, respectively. This compound also exhibits inhibitory activity against CDK1 with a Ki of 110 nM. Its ability to penetrate the blood-brain barrier makes CDK4/6-IN-3 a valuable candidate for research into glioblastoma therapies and other malignancies driven by dysregulated cell cycle progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2366237-37-6 |
| Applications | CDK4/CDK6 Inhibitor |
| Formula | C25H31FN8 |
| Molecular Weight | 462.57 |
| SMILES | FC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([C@H](C)CCCC6)N6N=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.