Fig. 1 · Structure
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CDK4/6-IN-7
CDK4/6 Inhibitor
CDK4/6-IN-7 is a potent and selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), with IC50 values of 1.58 nM and 4.09 nM, respectively. This orally active compound demonstrates significant biological activity, making it a valuable tool for investigating the role of CDK4/6 in various cancer models, particularly in breast cancer research. Its specificity and efficacy support studies aimed at understanding and targeting cell cycle progression in tumor cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2649120-20-5 |
| Applications | CDK4/6 Inhibitor |
| Formula | C18H18ClN5O3 |
| Molecular Weight | 387.82 |
| SMILES | O=C(C1=CC=CC=C1Cl)NNC(N2CCC[C@@H]2C(NC3=CC=CN=C3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.