CDK4-IN-1 is a selective inhibitor of Cyclin-dependent kinase 4 (CDK4), exhibiting an IC50 of 10 nM. This compound demonstrates significant specificity, being 1500-fold and 500-fold less potent against CDK1/Cyclin B and CDK2/Cyclin A, respectively, with IC50 values greater than 15 µM and 5 µM. CDK4-IN-1 is primarily utilized in research focused on cell cycle regulation and anti-cancer therapies, particularly in the context of cancers characterized by aberrant CDK4 activity.
CDK4-IN-1 is a selective inhibitor of Cyclin-dependent kinase 4 (CDK4), exhibiting an IC50 of 10 nM. This compound demonstrates significant specificity, being 1500-fold and 500-fold less potent against CDK1/Cyclin B and CDK2/Cyclin A, respectively, with IC50 values greater than 15 µM and 5 µM. CDK4-IN-1 is primarily utilized in research focused on cell cycle regulation and anti-cancer therapies, particularly in the context of cancers characterized by aberrant CDK4 activity.
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