Fig. 1 · Structure
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CDK6/9-IN-1
CDK6/9 Inhibitor
CDK6/9-IN-1 is a dual inhibitor of cyclin-dependent kinases 6 and 9, exhibiting IC50 values of 40.5 nM and 39.5 nM for CDK6 and CDK9, respectively. This compound demonstrates significant anti-proliferative activity, making it a valuable tool for studying cell cycle regulation and transcriptional control in various cancer models. It is particularly applicable in research focused on the therapeutic targeting of CDK pathways in oncogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2414373-55-8 |
| Applications | CDK6/9 Inhibitor |
| Formula | C22H25ClN8O |
| Molecular Weight | 452.94 |
| SMILES | CC(NC1=CC=CC(NC2=NC(NC3=NC=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.