Fig. 1 · Structure
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CDK7-IN-4
CDK7 Inhibitor
CDK7-IN-4 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7), a crucial regulator of cell cycle progression and transcriptional control. This compound exhibits significant anticancer activity by selectively inhibiting the proliferation of various cancer cell lines, including those derived from colon, breast, lung, ovary, and stomach tumors, in a dose-dependent manner. CDK7-IN-4 serves as a valuable tool for research into cancer therapeutics and the underlying mechanisms of CDK7-related oncogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2326428-25-3 |
| Applications | CDK7 Inhibitor |
| Formula | C26H39N7O3 |
| Molecular Weight | 497.63 |
| SMILES | CC(C1=C2N(N=C1)C(NC3CCN(CC3)C(OC4CN(CC4)C(/C=C/CN(C)C)=O)=O)=CC(C)=N2)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.