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CDK8-IN-10

Catalog No.: A54359
CDK8 Inhibitor
CDK8-IN-10 is a selective inhibitor of cyclin-dependent kinase 8 (CDK8), exhibiting an IC50 value of 8.25 nM. This compound is instrumental in the study of CDK8's role in cancer progression and may provide insights into therapeutic strategies targeting this kinase. Its potency and selectivity make it a valuable tool for cancer research applications.
CDK8-IN-10 2457317-40-5 CDK8 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCDK8-IN-10 is a selective inhibitor of cyclin-dependent kinase 8 (CDK8), exhibiting an IC50 value of 8.25 nM. This compound is instrumental in the study of CDK8's role in cancer progression and may provide insights into therapeutic strategies targeting this kinase. Its potency and selectivity make it a valuable tool for cancer research applications.
Product Information
Catalog NumA54359
FormulaC25H15ClF3N5O3
Molecular Weight525.87
CAS Number2457317-40-5
SMILESO=C(NC1=CC=C(N2C3=CC=NC=C3)C(OC4=NC=CC=C4C2=O)=C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
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Cell Cycle > CDK