Fig. 1 · Structure
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CDK8-IN-6
CDK8 Inhibitor
CDK8-IN-6 is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) with a Kd of 13 nM. This compound exhibits significant cytotoxic effects on various cancer cell lines, including MOLM-13, OCI-AML3, MV4-11, NRK, and H9c2, with IC50 values ranging from 7.5 to 25 µM. CDK8-IN-6 holds promise for advancing research in acute myeloid leukemia (AML) and related cancer studies, making it a valuable tool for investigating CDK8's role in tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2415156-27-1 |
| Applications | CDK8 Inhibitor |
| Formula | C26H37ClN2 |
| Molecular Weight | 413.04 |
| SMILES | C[C@@]12C(C3=CC(Cl)=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.