CDK8-IN-7 is a selective inhibitor of cyclin-dependent kinase 8 (CDK8), exhibiting a Kd of 3.5 nM. This compound demonstrates notable cytotoxicity across various cancer cell lines, including MOLM-13, OCI-AML3, MV4-11, NRK, and H9c2, with IC50 values ranging from 4.8 to 25 µM. CDK8-IN-7 is a valuable tool for investigating the role of CDK8 in acute myeloid leukemia (AML) and other related malignancies.
CDK8-IN-7 is a selective inhibitor of cyclin-dependent kinase 8 (CDK8), exhibiting a Kd of 3.5 nM. This compound demonstrates notable cytotoxicity across various cancer cell lines, including MOLM-13, OCI-AML3, MV4-11, NRK, and H9c2, with IC50 values ranging from 4.8 to 25 µM. CDK8-IN-7 is a valuable tool for investigating the role of CDK8 in acute myeloid leukemia (AML) and other related malignancies.
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