Fig. 1 · Structure
Documents & Downloads
CDK9/10/GSK3β-IN-1
Kinase Inhibitor
CDK9/10/GSK3β-IN-1 is a potent kinase inhibitor that targets CDK9, CDK10, and GSK3β. With IC50 values of 59 nM for GSK3β and 64 nM for CDK9/CyclinT, this compound demonstrates significant anti-cancer efficacy, exhibiting high anti-proliferative activity in vitro across various cancer cell lines. Its mechanism suggests potential applications in cancer research, particularly in studying the role of these kinases in cell cycle regulation and tumor progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2423045-06-9 |
| Applications | Kinase Inhibitor |
| Formula | C29H24ClN3O4S |
| Molecular Weight | 546.04 |
| SMILES | ClC1=CC(SC2=NC3=CC=CC=C3N2C)=CC=C1C(OC4=C5C(O)=CC(O)=C4C(CC6)=CCN6C)=CC5=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.