CDK9-IN-19 is a selective inhibitor of Cyclin-Dependent Kinase 9 (CDK9), exhibiting a potent IC50 value of 2.0 nM. This compound demonstrates significant antiproliferative activity in cellular assays and effectively suppresses tumor growth in MV4-11 xenograft models. With moderate pharmacokinetic properties and minimal hERG inhibition, CDK9-IN-19 is valuable for research on acute myeloid leukemia (AML) and related oncogenic pathways.
CDK9-IN-19 is a selective inhibitor of Cyclin-Dependent Kinase 9 (CDK9), exhibiting a potent IC50 value of 2.0 nM. This compound demonstrates significant antiproliferative activity in cellular assays and effectively suppresses tumor growth in MV4-11 xenograft models. With moderate pharmacokinetic properties and minimal hERG inhibition, CDK9-IN-19 is valuable for research on acute myeloid leukemia (AML) and related oncogenic pathways.
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