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CDK9-IN-8

CDK9 inhibitor

CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.

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Biological Activity

Target & Activity

Target	Activity	Value
CDK9	IC50	12 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A549	IC50	456 nM	Growth inhibition of human A549 cells incubated for 72 hrs by CCK8 assay	[PMID: 28651979]
MCF7	IC50	338 nM	Growth inhibition of human MCF7 cells incubated for 72 hrs by CCK8 assay	[PMID: 28651979]
NCI-H1299	IC50	221 nM	Growth inhibition of human H1299 cells incubated for 72 hrs by CCK8 assay	[PMID: 28651979]
NCI-H460	IC50	359 nM	Growth inhibition of human H460 cells incubated for 72 hrs by CCK8 assay	[PMID: 28651979]
T47D	IC50	358 nM	Growth inhibition of human T47D cells incubated for 72 hrs by CCK8 assay	[PMID: 28651979]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2105956-51-0
Applications	CDK9 inhibitor
Formula	C₃₁H₃₂FN₇O₃
Molecular Weight	569.63
SMILES	FC1=CC=C(NC(C2(CC2)C(NC3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(N(C)C)=O)=C5)=N4)C=C3)=O)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.