Fig. 1 · Structure
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CDK9-IN-9
CDK9 Inhibitor
CDK9-IN-9 is a selective inhibitor of cyclin-dependent kinase 9 (CDK9), exhibiting an IC50 of 1.8 nM. This compound also demonstrates some activity against CDK2, with an IC50 of 155 nM. CDK9-IN-9 has been shown to possess anti-cancer properties, making it a valuable tool for research applications focused on cancer biology and therapeutic development targeting transcriptional regulation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2246956-84-1 |
| Applications | CDK9 Inhibitor |
| Formula | C22H23F2N5O2S |
| Molecular Weight | 459.51 |
| SMILES | CS(CC1=CC2=CC(NC3=NC=C(C(C4=CC=C(C(NCCCCO2)=C4)F)=N3)F)=C1)(=O)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.