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CE-1037

HNE Inhibitor

CE-1037 is a selective inhibitor of human neutrophil elastase (HNE), exhibiting a Ki value of 0.45 nM. This compound effectively prevents pulmonary hemorrhage induced by the intratracheal instillation of HNE. CE-1037 is valuable for research into pulmonary diseases, particularly chronic obstructive pulmonary disease (COPD), allowing for in-depth studies of its pathophysiology and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	150493-09-7
Applications	HNE Inhibitor
Formula	C₃₆H₄₂O₁₂S₂
Molecular Weight	730.84
Synonyms	MDL 201,404YA
SMILES	O=S(C1=CC=C(OC(C(C2=CC=C(C(C(OC3=CC=C(S(=O)(CC(C(O)=O)(C)C)=O)C=C3)=O)(C)C)C=C2)(C)C)=O)C=C1)(CC(C)(C)C(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.