CE-245677

Catalog No.: A19377

Tie2 and TrkA/B inhibitor

CE-245677

CE-245677 Chemical Structure

CAS NO. 717899-97-3

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.48 mL 97.39 mL 194.79 mL
0.5 mM 3.9 mL 19.48 mL 38.96 mL
1 mM 1.95 mL 9.74 mL 19.48 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 513.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19377
Actions Inhibitor
CAS No. 717899-97-3
Formula C24H22Cl2N6O3
M. Wt 513.38
Solubility DMSO
Purity >98%
Synonyms CE245677, CE 245677
SMILES O=C(NC1=CC=C(Cl)C=C1Cl)NC2=CC(C(C3=CN(C(C)C)C4=NC=NC(N)=C43)=O)=CC=C2OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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