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Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.65 mL | 88.25 mL | 176.5 mL |
| 0.5 mM | 3.53 mL | 17.65 mL | 35.3 mL |
| 1 mM | 1.76 mL | 8.82 mL | 17.65 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.53 mL |
*The above data is based on the productmolecular weight 566.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21857 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 566.58 |
| Formula | C29H31FN4O7 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 857036-77-2 |
| Synonyms | AZD-2171 maleate, AZD2171, AZD 2171 |
| SMILES | O=C(O)/C=C\C(O)=O.FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5 |
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