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Cefepime hydrochloride

hPON1 Inhibitor

Cefepime hydrochloride is a potent hPON1 inhibitor that operates through a non-competitive mechanism, exhibiting an IC50 of 21.115 mM and a Ki of 35.092 mM. This broad-spectrum cephalosporin antibiotic effectively crosses the blood-brain barrier, demonstrating significant antibacterial activity against both Gram-positive and Gram-negative bacteria without inducing β-lactamase production. Its ability to block GABAA receptors further highlights its multifaceted therapeutic potential in chemical research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	107648-80-6
Applications	hPON1 Inhibitor
Formula	C₁₉H₂₆Cl₂N₆O₅S₂
Molecular Weight	553.48
Synonyms	BMY-28142 hydrochloride
SMILES	OC(C(N(C1=O)[C@@](SC2)([H])[C@@H]1NC(/C(C3=CSC(N)=N3)=N\OC)=O)=C2C[N+]4(CCCC4)C)=O.[Cl-].Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.