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APC/C inhibitors support research on the anaphase-promoting complex/cyclosome and mitotic control. This ubiquitin ligase marks cell cycle regulators for degradation, coordinating chromosome separation and exit from mitosis. Its activity depends on regulatory proteins and the spindle assembly checkpoint. The category contains proTAME and apcin, together with other APC/C-related reagents. It also includes tools associated with adenomatous polyposis coli, a different protein that shares the APC abbreviation. These distinct target groups should be separated when selecting reagents for cell cycle studies.
