Fig. 1 · Structure
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Tebapivat
Cat. No.
A77400
CAS
2283422-04-6
Pyruvate Kinase-R Activator
Tebapivat is a potent activator of pyruvate kinase-R (PKR), playing a critical role in enhancing glycolytic flux and energy metabolism. Its ability to stimulate PKR makes it valuable in research on metabolic disorders and cancer, where glycolysis is often dysregulated. Tebapivat can be utilized to investigate the effects of PKR activation on cellular energy production and related biochemical pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2283422-04-6 |
| Applications | Pyruvate Kinase-R Activator |
| Formula | C18H16N8OS |
| Molecular Weight | 392.44 |
| Synonyms | AG-946; PKR activator 2 |
| SMILES | O=C1C(N(C)C2=C3SC(CC4=NNC=C4)=N2)=C3C=NN1CC5=NC(N)=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.