Fig. 1 · Structure
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PKM2 activator 2
Cat. No.
A77401
CAS
1186660-06-9
PKM2 Activator
PKM2 activator 2 is a potent activator of pyruvate kinase M2 (PKM2) with an AC50 value of 66 nM. This compound effectively enhances PKM2 activity, facilitating the restoration of normal glycolytic metabolism in various cellular models. It is valuable for research applications focusing on cancer metabolism and cellular energy regulation, offering insights into metabolic reprogramming in tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1186660-06-9 |
| Applications | PKM2 Activator |
| Formula | C20H18F2N2O4S2 |
| Molecular Weight | 452.49 |
| SMILES | FC1=C(S(=O)(N2CCN(S(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)=O)C(F)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.