Malonyl-NAC is a specific inhibitor of GAPDH malonylation that leads to decreased endogenous GAPDH activity in cells. This reagent enhances GAPDH malonylation and concurrently inhibits pyruvate kinase activity. It has been shown to limit metabolism and proliferation in highly glycolytic kidney cancer cell lines possessing tricarboxylic acid cycle mutations, making it a valuable tool for investigating metabolic alterations in cancer research.
Malonyl-NAC is a specific inhibitor of GAPDH malonylation that leads to decreased endogenous GAPDH activity in cells. This reagent enhances GAPDH malonylation and concurrently inhibits pyruvate kinase activity. It has been shown to limit metabolism and proliferation in highly glycolytic kidney cancer cell lines possessing tricarboxylic acid cycle mutations, making it a valuable tool for investigating metabolic alterations in cancer research.
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