Fig. 1 · Structure
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malonyl-NAC
Cat. No.
A77404
CAS
2361327-06-0
GAPDH malonylation
Malonyl-NAC is a specific inhibitor of GAPDH malonylation that leads to decreased endogenous GAPDH activity in cells. This reagent enhances GAPDH malonylation and concurrently inhibits pyruvate kinase activity. It has been shown to limit metabolism and proliferation in highly glycolytic kidney cancer cell lines possessing tricarboxylic acid cycle mutations, making it a valuable tool for investigating metabolic alterations in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2361327-06-0 |
| Applications | GAPDH malonylation |
| Formula | C9H15NO4S |
| Molecular Weight | 233.28 |
| SMILES | O=C(CC(SCCNC(C)=O)=O)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.